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Mikael Elinder - Institutet för Näringslivsforskning

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Arv 471

ARV-471 degrades ERamutants ARV-471 is a potent ERadegrader SABCS, Dec 4-8, 2018 MCF7 / estradiol Summary • Orally-bioavailable ARV-471 demonstrates single-digit nanomolar ERadegradation potency in wild-type and variant ERa-expressing cell lines • ARV-471 displays no agonist activity in rodent uterine tissue ARV-471, an estrogen receptor (ER) alpha PROTAC, is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex, leading to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. For ARV-471, interim Phase 1 data show potential for best-in-class safety and tolerability, estrogen receptor (ER) degradation superior to that previously reported for the current standard of care Arvinas' ARV-110 and ARV-471 are PROTAC molecules that respectively target the degradation of androgen receptor (AR) and estrogen receptor (ER). The previously announced preliminary clinical trial results showed that ARV-471 had the potential to be a best-in-class estrogen receptor degrading agent. Arvinas will start a phase 1b combination trial with Pfizer’s CDK4/6 inhibitor Ibrance by the end of the year and kick off a phase 2 dose expansion of ARV-471 in the first half of 2021. US-based biotechnology firm Arvinas has reported positive data from the ongoing Phase I clinical trials of its cancer drug candidates, ARV-110 and ARV-471. Based on the company’s PROTAC platform, ARV-110 and ARV-471 are protein degrader products that target the androgen receptor (AR) and the oestrogen receptor (ER), respectively.

Tillståndsansökan Ryds ARV - Tingsryds kommun

2 702 623. 2 471 500. 2 524 267 Antal telefonkontakter privata specialister, ARV. under våren, i samverkan med Nordens ark, kursen ”BIO471 historiemedvetande eftersom ett arv aldrig kan delas utanför gruppen Strömsunds ARV. 2019-05- Göviken ARV, ord. recipientprovp.

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Arvinas Corporate Presentation – March 2021. March 16, 2021. Clinical Program Update: ARV-471 & ARV-110.